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Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region
Zhiyuan Zhang
《医学前沿(英文)》 2011年 第5卷 第4期 页码 401-413 doi: 10.1007/s11684-011-0161-7
关键词: bone regeneration animal models translational strategies oral and maxillofacial region
Error analysis and optimization of a 3-degree of freedom translational Parallel Kinematic Machine
null
《机械工程前沿(英文)》 2014年 第9卷 第2期 页码 120-129 doi: 10.1007/s11465-014-0300-3
In this paper, error modeling and analysis of a typical 3-degree of freedom translational Parallel Kinematic Machine is presented. This mechanism provides translational motion along the Cartesian X-, Y- and Z- axes. It consists of three limbs each having an arm and forearm with prismatic-revolute-revolute-revolute joints. The moving or tool platform maintains same orientation in the entire workspace due to its joint arrangement. From inverse kinematics, the joint angles for a given position of tool platform necessary for the error modeling and analysis are obtained. Error modeling is done based on the differentiation of the inverse kinematic equations. Variation of pose errors along X, Y and Z directions for a set of dimensions of the parallel kinematic machine is presented. A non-dimensional performance index, namely, global error transformation index is used to study the influence of dimensions and its corresponding global maximum pose error is reported. An attempt is made to find the optimal dimensions of the Parallel Kinematic Machine using Genetic Algorithms in MATLAB. The methodology presented and the results obtained are useful for predicting the performance capability of the Parallel Kinematic Machine under study.
关键词: translational Parallel Kinematic Machine error modeling global error transformation index
Numerical analysis of hydrodynamic process of circular-translational-moving polishing (CTMP)
ZHAI Wenjie, LIU Changxiong, LIANG Yingchun
《机械工程前沿(英文)》 2008年 第3卷 第4期 页码 441-448 doi: 10.1007/s11465-008-0074-6
关键词: numerical analysis practical CTMP circular-translational-moving polishing CTMP different
《医学前沿(英文)》 2022年 第16卷 第4期 页码 551-573 doi: 10.1007/s11684-022-0928-z
关键词: HCC bone osteotropism clinical basic researches advances
Stiffness of a 3-degree of freedom translational parallel kinematic machine
null
《机械工程前沿(英文)》 2014年 第9卷 第3期 页码 233-241 doi: 10.1007/s11465-014-0312-z
In this paper, a typical 3-degree of freedom (3-DOF) translational parallel kinematic machine (PKM) is studied and analyzed whose tool platform has only translations along X-, Y- and Z-axes. It consists of three limbs, each of which have arm and forearm with prismatic-revolute-revolute-revolute (PRRR) joints. Inverse kinematics analysis is carried out to find the slider coordinates and joint angles for a given position of tool platform. Stiffness modeling is done based on the compliance matrices of arm and forearm of each limb. Using the stiffness modeling the variations of minimum and maximum translational stiffness in the workspace are analyzed. For various architectural parameters of the 3-DOF PKM the tendency of variations on the minimum and maximum stiffness over the entire workspace is studied; and also the deflections of the tool platform along X, Y, and Z directions with respect to various forces are presented.
关键词: 3-DOF translational PKM inverse kinematics stiffness modeling translational stiffness
Conceptual design of compliant translational joints for high-precision applications
Guangbo HAO,Haiyang LI,Xiuyun HE,Xianwen KONG
《机械工程前沿(英文)》 2014年 第9卷 第4期 页码 331-343 doi: 10.1007/s11465-014-0321-y
Compliant translational joints (CTJs) have been extensively used in precision engineering and microelectromechanical systems (MEMS). There is an increasing need for designing higher-performance CTJs. This paper deals with the conceptual design of CTJs via three approaches: parallelogram based method, straight-line motion mechanism based method and combination based method. Typical emerging CTJ designs are reviewed by explaining their design principles and qualitatively analyzing their characteristics. New CTJs are proposed using three approaches, including an asymmetric double parallelogram mechanism with slaving mechanism, several compact and symmetric double parallelogram mechanisms with slaving mechanisms and a general CTJ using the center drift compensation and a CTJ using Roberts linkage and several combination designs. This paper provides an overview of the current advances/progresses of CTJ designs and lays the foundation for further optimization, quantitative analysis and characteristic comparisons.
关键词: compliant mechanisms translational joints conceptual design parallelogram straight-line motion combination method
Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine
Hongmei Xu, Xuetao Cao
《医学前沿(英文)》 2011年 第5卷 第4期 页码 323-332 doi: 10.1007/s11684-011-0172-4
《机械工程前沿(英文)》 2022年 第17卷 第3期 doi: 10.1007/s11465-022-0695-1
关键词: translational parallel mechanism single loop multiple driving system workspace analysis singularity
Overcoming the challenges of conducting translational research in cell therapy
Sowmya Viswanathan, Armand Keating
《医学前沿(英文)》 2011年 第5卷 第4期 页码 333-335 doi: 10.1007/s11684-011-0166-2
关键词: stem cells clinical trials funding animal models standardization common definitions
Jisheng Han, Cailian Cui, Liuzhen Wu
《医学前沿(英文)》 2011年 第5卷 第2期 页码 141-150 doi: 10.1007/s11684-011-0136-8
关键词: morphine dependence withdrawal addiction dynorphins acupuncture electroacupuncture transcutaneous electrical acupoint stimulation (TEAS) enkephalins endorphins
Translational research on novel drug-eluting stents in percutaneous coronary intervention
Yaling Han, Kai Xu, Chenghui Yan
《医学前沿(英文)》 2011年 第5卷 第4期 页码 395-400 doi: 10.1007/s11684-011-0167-1
关键词: translational research drug-eluting stents percutaneous coronary intervention
《医学前沿(英文)》 2022年 第16卷 第5期 页码 745-759 doi: 10.1007/s11684-021-0880-3
关键词: insulin resistance non-alcoholic fatty liver disease Chinese herbal medicine randomized controlled trial DNA N6-methyladenine modification
Translational medicine promising personalized therapy in oncology
Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 351-355 doi: 10.1007/s11684-010-0320-2
《医学前沿(英文)》 doi: 10.1007/s11684-023-1016-8
关键词: p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response
Translational initiatives in thrombolytic therapy
null
《医学前沿(英文)》 2017年 第11卷 第1期 页码 1-19 doi: 10.1007/s11684-017-0497-8
Once thrombi have formed as part of the pathology defining myocardial infarction, ischemic stroke, peripheral arterial disease, deep venous thrombosis or other embolic disorders, the only clinically meaningful thrombolytic agents available for reversing the thrombogenic process are various plasminogen activators. These agents are enzymes that reverse fibrin polymerization underlying the coagulation process by converting endogenous plasminogen to plasmin, which cleaves the fibrin network to form increasingly smaller protein fragments, a process known as fibrinolysis. For the most part, the major clinically used thrombolytics, tissue plasminogen activator, urokinase and streptokinase, as well as the experimentally investigated agent staphylokinase, are the products of recombinant DNA technology, which permits molecular optimization of clinical efficacy. In all cases of molecular optimization and targeting, however, the primary challenge of thrombolytic therapy remains hemorrhagic side effects, which are especially devastating when they occur intracerebrally. Currently, the best strategy to ameliorate this adverse effect is nanoparticulate encapsulation or complexation, and many strategies of this sort are being actively pursued. This review summarizes the variety of targeted and untargeted thrombolytic formulations that have been investigated in preclinical studies.
标题 作者 时间 类型 操作
Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region
Zhiyuan Zhang
期刊论文
Error analysis and optimization of a 3-degree of freedom translational Parallel Kinematic Machine
null
期刊论文
Numerical analysis of hydrodynamic process of circular-translational-moving polishing (CTMP)
ZHAI Wenjie, LIU Changxiong, LIANG Yingchun
期刊论文
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives
期刊论文
Conceptual design of compliant translational joints for high-precision applications
Guangbo HAO,Haiyang LI,Xiuyun HE,Xianwen KONG
期刊论文
Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine
Hongmei Xu, Xuetao Cao
期刊论文
Design and analysis of partially decoupled translational parallel mechanisms with single-loop structures
期刊论文
Overcoming the challenges of conducting translational research in cell therapy
Sowmya Viswanathan, Armand Keating
期刊论文
Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine
Jisheng Han, Cailian Cui, Liuzhen Wu
期刊论文
Translational research on novel drug-eluting stents in percutaneous coronary intervention
Yaling Han, Kai Xu, Chenghui Yan
期刊论文
improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational
期刊论文
Translational medicine promising personalized therapy in oncology
Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,
期刊论文
Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational
期刊论文